The 'Uh Oh Sisters' meme is a satirical play on beauty influencer James Charles’ signature 'Hi Sisters' catchphrase, often associated with the infamous 'Flashback Mary' photo or other startled, high-contrast facial expressions. It gained massive traction on platforms like TikTok and Twitter as a reaction to impending drama, problematic behavior, or comedic jump-scare scenarios. While Charles originally intended his greeting to be welcoming to his fanbase, the internet repurposed the audio and imagery to create a sense of mock dread and chaos. Today, it remains a staple for internet culture commentary, used whenever a situation goes from bad to worse in the flash of a ring light.