The 'It's Not Lupus' meme originates from the long-running medical drama House, M.D., where the diagnostic team frequently suggested systemic lupus erythematosus as a possible cause for patients' mysterious symptoms. Dr. Gregory House, played by Hugh Laurie, became famous for dismissing the suggestion with his cynical catchphrase, 'It’s never lupus.' This recurring theme became a running gag among fans, highlighting the show's formulaic structure. In internet culture, the meme is used to mock people who provide overly complex yet incorrect explanations for simple problems, or to celebrate the inevitable dismissal of common tropes. It represents the frustration of hearing the same wrong answer over and over, wrapped in the sarcastic wit of TV's most famous misanthrope.