The House M.D. meme cycle revolves around the eccentric and misanthropic protagonist, Dr. Gregory House, from the iconic medical drama series. These memes typically leverage the character's signature catchphrases, such as 'Everybody lies' or the running gag that a patient's condition is 'never lupus.' Templates often feature House pointing at his diagnostic whiteboard, leaning on his cane with a skeptical expression, or engaging in dry wit with his team. In internet culture, these images are used to call out obvious deceptions, mock unnecessarily complex explanations, or simply channel a mood of intellectual arrogance and weary cynicism toward the world.