The 'Weaklings Die. Big Deal' meme features the character Zero Two from the popular anime series 'Darling in the Franxx.' The scene occurs in the first episode where she dismisses the death of a fellow pilot with cold indifference. This particular screencap gained massive traction within the anime community on platforms like Reddit and Twitter as a reaction image for displaying extreme apathy or superiority. It is often used to mock things that break easily, people who complain about minor hardships, or to humorously portray a 'survival of the fittest' mentality in everyday situations like gaming or tech failures.