The 'U Ever Flex on Niggas' meme typically features a screenshot of Squidward Tentacles from SpongeBob SquarePants, often depicted in a state of exhaustion, suspicion, or intense focus. It originated as a piece of ironic street humor, where the 'flex' involves doing something completely mundane, useless, or nonsensical just to show off. The humor stems from the juxtaposition of the aggressive slang with the triviality of the action described. Over time, the template has evolved to include various characters, but the Squidward variant remains the most recognizable version, serving as a staple in surreal and deep-fried meme communities.