The 'Peter Griffin Running Away from a Plane' meme is a direct parody of the famous crop duster chase scene from Alfred Hitchcock’s 1959 thriller, 'North by Northwest.' Featured in the Family Guy episode 'North by North Quahog,' the scene depicts Peter running through a cornfield as a plane pursues him from behind. Internet users typically use this template to represent situations where someone is desperately fleeing from an overwhelming problem, a looming responsibility, or an awkward social interaction. It has become a staple in the Family Guy meme library for its dramatic yet slapstick visual appeal.