High On Life, released in late 2022, quickly became a meme powerhouse due to its unique premise of sentient, foul-mouthed weaponry and its signature improvisational humor style. The memes typically center around the game's protagonist weapons, particularly Kenny, reacting to the player's actions or the bizarre alien environments. Usage often involves placing the talking guns in relatable real-world situations or using their expressive faces to convey shock, judgment, or confusion. As a blend of sci-fi action and absurdist comedy, the game provides a rich library of reaction images that capture the feeling of being overwhelmed by sheer weirdness.