This high-energy clip originates from the 2018 YouTube sketch titled 'When you take DayQuil and NyQuil at the same time' by the prolific creator Caleb Glass, better known as CalebCity. In the scene, Caleb plays the role of a man who has made a grave medicinal error, resulting in two personified versions of the medicine battling for control over his body. The viewer sees Caleb violently oscillating between 'DayQuil'—represented by wide eyes and vibrating energy—and 'NyQuil'—represented by an instant, heavy-headed collapse into sleep. This physical comedy masterfully captures the sensation of extreme neurological confusion and physical exhaustion. In internet culture, this template is the gold standard for representing 'tired but wired' scenarios or any situation involving conflicting internal impulses. It is commonly used to describe the feeling of drinking caffeine while sleep-deprived or having a panic attack while trying to take a nap. Example captions include: 'When you take a 5-hour energy at 11 PM to finish an essay,' 'My last two brain cells fighting for dominance during the math final,' and 'Me trying to stay awake in class after pulling an all-nighter.'