The 'Are You Sure About That?' meme originates from a clip featuring professional wrestler and actor John Cena during a segment for the WWE YouTube channel. In the video, Cena playfully pokes his head through a green screen background to interrupt a speaker with his now-famous skeptical inquiry. It quickly became a viral sensation, used primarily as a reaction video or image to challenge someone's dubious claims, overconfident statements, or obvious lies. The meme's appeal lies in Cena’s sudden, unexpected appearance and the comedic timing of his delivery, making it the perfect template for debunking myths or highlighting poor life choices.