The '0% Risk of Transmission' meme is based on a healthcare infographic that originally circulated during the COVID-19 pandemic to illustrate how masks reduce the spread of the virus. The chart shows different scenarios of mask-wearing between two individuals and the resulting percentage of infection risk. Internet users quickly hijacked the '0% risk' scenario—usually where both parties are wearing masks—and replaced the subjects or context with things that would realistically prevent any social interaction or 'transmission' of anything, such as playing specific video games, having niche interests, or being socially awkward. It serves as a self-deprecating way to joke about isolation and subculture tropes.