Disease X is a term adopted by the World Health Organization to represent a hypothetical, unknown pathogen that could cause a future pandemic. While intended for scientific preparedness, the internet quickly turned the term into a viral sensation fueled by a mix of cynicism and dark humor. Memes typically revolve around pandemic fatigue, skepticism of global health headlines, or comparisons to previous lockdowns. It is frequently used by social media users to express a 'here we go again' sentiment or to satirize the sensationalist nature of modern news reporting.