The 'Yo' meme is most famously associated with the character Jesse Pinkman from the hit series Breaking Bad, who frequently used the word as a catchphrase, greeting, and exclamation. It has since transcended the show to become a universal internet reaction used to grab attention, express surprise, or simply start a conversation with a bit of attitude. The meme template usually features a character in a mid-shout or casual stance, allowing users to pair the 'Yo' with various punchlines. Its simplicity makes it one of the most enduring and versatile reaction formats in digital culture, perfect for everything from niche fandom jokes to everyday social media banter.