The 'Giant Enemy Spider' meme originated from a Twitch stream by the variety streamer Jerma985. During a playthrough of Pokémon FireRed, Jerma began beatboxing a dramatic boss-battle theme while announcing the arrival of 'The Giant Enemy Spider' in a high-pitched, energetic voice. The audio clip gained massive traction years later on platforms like YouTube and TikTok, often paired with low-quality 3D models of spiders or distorted visuals. It is primarily used as a bait-and-switch meme or a humorous way to signal a chaotic, unexpected boss encounter. The meme's lasting appeal lies in Jerma's frantic vocal performance and its versatility in being edited into various video games and real-life scenarios.