The 'That Post Gave Me Cancer' meme is a staple of early internet culture, primarily popularized on imageboards like 4chan and Reddit during the mid-2000s. It is used as a hyperbolic reaction to posts that are perceived as incredibly low-quality, 'cringey,' or nonsensical, suggesting the content was so bad it caused physical distress. Often paired with an image of 1960s Spider-Man in a hospital bed or various characters looking physically pained, it remains a go-to expression for extreme disapproval. While the humor is dark and edgy, it captures the raw, unfiltered frustration of social media users encountering particularly subpar content.