The 'Enjoy Your AIDS' meme originated as a single panel from a webcomic depicting a character presenting a gift with a disturbingly cheerful expression. It gained notoriety on imageboards during the early 2010s as a quintessential 'shock' reaction image. The humor relies on the extreme juxtaposition between the character's polite gesture and the malicious nature of the dialogue. It is typically used in online discourse as a way to 'troll' someone or to sarcastically celebrate a bad situation with a dark, nonsensical punchline.