The Stop Girl meme originated from a 2010 broadcast of an Arizona Wildcats football game against the Iowa Hawkeyes. The footage features a young fan, later identified as Sarah, who realizes she is being filmed and playfully mouths the word 'stop' while laughing and looking down bashfully. The clip gained massive popularity on Reddit and Imgur in 2012 due to her charming reaction. It is primarily used as a wholesome response to compliments, flirtatious comments, or overwhelmingly cute content where a person feels playfully embarrassed or 'attacked' by kindness.