The 'Stop Calling me a Homo!' meme revolves around the humorous linguistic confusion between the scientific term 'Homo sapien' and the shorthand slang 'homo.' It typically features a character reacting with intense, misplaced anger to being called a human, demonstrating a lack of scientific knowledge for comedic effect. This trope has appeared in various forms across internet history, from early rage comics to viral forum posts and educational skits. It is widely used to highlight situations where someone gets offended by a fact they don't quite understand, making it a staple of 'confidently incorrect' internet humor.