The 'Squidward Trying to Sleep' meme originates from the Season 4 episode of SpongeBob SquarePants titled 'Good Neighbors.' In the scene, Squidward is seen lying in bed, desperately attempting to get some rest while SpongeBob and Patrick cause chaos outside. The meme typically depicts the relatability of insomnia, anxiety, or external disturbances that prevent one from falling asleep. It gained massive popularity across platforms like Reddit and Twitter as a way to visualize the brain's activity at 3 AM or the sudden intrusion of embarrassing memories. Its versatility makes it a staple for anyone wanting to poke fun at their own late-night struggles or the frustrations of dealing with uncontrollable surroundings.