Scary Movie 4, released in 2006, features the legendary comedic duo of Anna Faris as Cindy Campbell and Regina Hall as Brenda Meeks in another chaotic horror parody. In this scene, Brenda delivers her instantly iconic line, "Lol shut up," with a level of dismissive sass that only Regina Hall could pull off. The clip captures the moment Brenda completely ignores Cindy's serious concerns, opting instead to mock her for being dramatic. This specific interaction has transcended the film to become one of the most recognizable reaction clips on social media. The meme is widely used to represent situations where someone is giving unsolicited advice, sharing boring news, or being overly emotional. It perfectly captures the energy of being totally unbothered while someone else is talking your ear off. Example caption ideas include: "When the barista tells me they are out of oat milk," "Me when someone tries to explain cryptocurrency to me," and "When your ex starts a text with 'I've been thinking...'"