The Sad Megamind meme, widely recognized for the 'No Bitches?' caption, features a distorted, extreme close-up of the protagonist from the 2010 DreamWorks film Megamind. While the image appeared in promotional material and the movie itself, it gained massive popularity in late 2021 and early 2022 as a reaction image. It is typically used to mock or taunt someone for lacking something specific—most famously 'bitches'—by using a fish-eye lens effect that makes Megamind appear both pitiful and condescending. The format has since evolved to include various 'No [X]?' variations, making it a versatile tool for internet banter.