The 'No Bitches?' meme features a distorted, close-up image of the protagonist from the 2010 animated film Megamind. It first gained viral traction on Twitter and Reddit in early 2022 as a sarcastic reaction image used to mock someone's lack of success or possession of a specific item. The image is notable for its extreme fisheye-lens effect and the character's smug expression. While the original caption asks 'No Bitches?', the format has evolved into a versatile 'No [X]?' template, allowing users to substitute any subject to create a condescending retort.