The 'Sad Bill Murray' meme primarily stems from a 2016 televised moment during the NCAA tournament, where the legendary actor was caught on camera looking utterly devastated after the Xavier Musketeers suffered a last-second defeat. His blank, soul-crushing stare instantly resonated with the internet, becoming a universal symbol for profound disappointment and the quiet existential dread of everyday life. While Murray has a career built on 'sad-clown' performances in films like Lost in Translation, this real-life candid shot cemented his status as the patron saint of being 'over it.' Today, the meme is widely used to capture the feeling of realizing a situation has gone south or simply staring into the void of modern existence.