The Running Butthole Challenge refers to a viral social media trend, primarily popular on platforms like TikTok and Instagram, where users apply a specific distortion filter to a video of someone running. The filter often creates a puckered, circular focal point on the runner's face or body, leading to the humorous and slightly absurd nickname. The meme is typically used to represent someone frantically fleeing from a situation, such as awkward social encounters, looming responsibilities, or bad news, amplified by the chaotic visual energy of the filter. Since its inception, the challenge has inspired countless variations, making it a staple for relatability and surreal humor in digital content creation.