The 'I Wonder What's Inside Your Butthole' meme originates from an early YouTube video featuring a young Jojo Siwa performing an absurdist, nonsensical song. While the clip had been online for years, it resurfaced as a massive viral trend on TikTok and Twitter around 2020. The humor stems from the jarring, bizarre nature of the lyrics contrasted with Jojo’s high-energy, childlike performance style. It is frequently used as a reaction video to express curiosity about something hidden or as a complete non-sequitur to derail a serious conversation. Its longevity in internet culture is fueled by its sheer weirdness and its status as a foundational piece of 'cringe' comedy history.