The 'Running All Over the Place Blue in the Face / Shi is Bubonic' meme originates from a high-energy viral audio clip that has taken social media by storm. In the audio, a voice rhythmically shouts about someone being 'bubonic,' a slang term used here to describe extreme, chaotic, or hyperactive behavior. This template is most commonly used on TikTok and Instagram to highlight pets, toddlers, or friends who are acting completely wild and uncontrollable. It has become the definitive internet anthem for pure, unhinged energy and zoomies, capturing those moments where life feels fast-paced and hilariously overwhelming.