The 'Run' meme primarily stems from the 2010 song 'Run' by the electronic rock band Awolnation. The track's heavy, suspenseful build-up followed by a sudden bass drop and the shouted lyric 'RUN!' became a staple on Vine and later TikTok. It is typically paired with footage of someone realizing they are in immediate danger or witnessing something terrifying, leading to a frantic escape. The meme transcends specific imagery, often being applied to animals, video game glitches, or relatable social blunders where the only logical response is to flee the scene as fast as possible.