The 'Pissing All By Yourself, Handsome?' meme originated from an edited manga panel, most famously featuring Guts from Berserk, though it has since been adapted across various fandoms. The image typically depicts a character approaching another at a public urinal and delivering an absurdly flirtatious or confrontational line. It gained massive popularity on platforms like Twitter and Reddit for its sheer unexpectedness and the awkward tension it portrays. Users often swap the characters for other fictional icons or use the template to mock social awkwardness, making it a staple of ironic 'bro' humor and manga-centric internet culture.