The 'Oh No, Doctor Connors' Class!' meme originates from the 2004 Spider-Man 2 video game, specifically the PC and console versions where Peter Parker must balance his superhero duties with his academic life. In the game, a notification or voice line often triggers, reminding the player that Peter is late for his physics class taught by Dr. Curt Connors, who famously becomes the Lizard. The meme gained traction in the late 2010s as a nostalgic callback to the game's frantic side-missions and occasionally awkward voice acting. It is commonly used to represent sudden anxiety, the realization of a missed deadline, or the struggle of balancing personal life with work or school.