The 'Nostalgia Critic Screaming No' meme features Doug Walker as his internet persona, the Nostalgia Critic, from his long-running web series 'Nostalgia Critic' which debuted in 2007. This specific high-intensity reaction is most frequently associated with his review of the 2003 film 'The Cat in the Hat,' where the Critic collapses into a state of total existential despair. In the clip, Walker screams a drawn-out, agonizing 'NOOOOO!' while clutching his head in frustration. It captures a moment of pure, unadulterated rejection of a horrific reality. Culturally, this clip is a staple 'Reaction' meme, used to represent someone witnessing a catastrophic failure or receiving devastatingly bad news. It is the go-to template for expressing horror at 'cursed' images or reacting to life's minor inconveniences that feel like world-ending events. Example caption ideas include: 'When you accidentally hit Reply All on a company email,' 'Seeing your bank balance after a weekend out,' and 'When the waiter says they are out of the one thing you wanted.'