The 'No Patrick' meme originates from the classic SpongeBob SquarePants episode 'Band Geeks,' which first aired in 2001. In the scene, Patrick Star raises his hand to ask if mayonnaise is an instrument, prompting Squidward's iconic deadpan response: 'No Patrick, mayonnaise is not an instrument.' The meme is widely used across the internet to highlight situations where someone asks an absurdly illogical question or fails to understand a basic concept. It has evolved into various formats, often replacing 'mayonnaise' with other ridiculous objects or ideas to fit different cultural contexts.