This iconic meme comes from the 2001 Band Geeks episode of SpongeBob SquarePants. During a rehearsal for Squidward's marching band, Patrick Star raises his hand to ask if mayonnaise is an instrument, to which Squidward famously replies that it is not. The scene became a legendary internet staple, used to represent blissful ignorance or to ask intentionally nonsensical questions in online forums and social media. It remains one of the most quoted and recognizable moments in animation history.