Nina Tucker is a central figure in one of anime’s most tragic and enduring memes, originating from the series Fullmetal Alchemist. The character is the young daughter of Shou Tucker, who infamously fuses her with her pet dog, Alexander, to create a talking Chimera to keep his state license. The meme typically centers on the haunting image of the Chimera calling out to the protagonist, Edward Elric, with the words 'Edward...' or 'Big Brother.' It is widely used across the internet as a benchmark for 'emotional damage' or dark humor, often appearing in 'if you know, you know' contexts to shock newcomers or mock the shared trauma of veteran anime fans.