Fullmetal Alchemist memes stem from the massive popularity of Hiromu Arakawa's manga and its two anime adaptations, particularly Fullmetal Alchemist: Brotherhood. The most recurring themes involve the Law of Equivalent Exchange, which fans often apply to relatable real-life trade-offs. Other viral moments include Edward Elric’s explosive reactions to being called short, Roy Mustang's obsession with tiny miniskirts, and the infamously tragic Nina Tucker incident that has become a dark staple of internet culture. These memes bridge the gap between deep philosophical questions and lighthearted anime tropes, making them a favorite across social media platforms like Reddit and Twitter.