Mista's Tetraphobia originates from the JoJo's Bizarre Adventure series, specifically Part 5: Golden Wind. It centers on the character Guido Mista, a gunman who suffers from a paralyzing fear of the number four, believing it to be a harbinger of extreme bad luck. This quirk is a recurring gag throughout the series, often leading to comedic moments of panic whenever the digit appears in his daily life or even in the count of his bullets. Online, the meme is used to express irrational fear, highlight bad luck, or simply to troll JoJo fans with anything containing the cursed digit. It remains one of the most recognizable character-specific tropes in the anime community.