The Mei's 'No' meme originates from the 2022 Disney/Pixar film Turning Red, specifically featuring the protagonist Meilin Lee. The template captures a moment of intense, panicked refusal or shock, characterized by Mei's expressive face and defensive posture. It became an instant hit on social media platforms like Twitter and TikTok shortly after the movie's release, as users found it the perfect visual shorthand for setting boundaries or reacting to absurd requests. Today, it is widely used to humorously decline social invitations, avoid responsibilities, or express relatable social anxiety in a vibrant, animated style.