The Martin Shkreli Fraud Trial meme stems from the 2017 legal proceedings of the controversial former pharmaceutical executive, often dubbed 'Pharma Bro.' Known for his high-profile price gouging of life-saving drugs and his provocative online presence, Shkreli's behavior in court—ranging from smug smirks to wearing casual hoodies—became an instant sensation. The meme typically highlights themes of unearned confidence, corporate greed, or the awkward moment when online personas clash with real-world consequences. It is widely used to represent someone who is 'in trouble but doesn't care' or to poke fun at technicalities in legal and financial situations.