The Mari Setogaya meme features the expressive reactions of the well-known Japanese personality, which have become staples of internet reaction culture. Often used to represent feelings of sudden realization, guilt, or 'if you know, you know' moments, these memes typically highlight a specific, wide-eyed or awkward expression that resonates with social media users. While her popularity originated in niche online circles, the template has evolved into a versatile tool for highlighting relatable social situations or inside jokes. Today, the Mari Setogaya meme is widely recognized across platforms like Twitter and Reddit as a go-to reaction for when a facial expression says more than words ever could.