The Madame Web meme cycle began almost immediately after the release of the film's first trailer in late 2023. The internet latched onto a specific, oddly delivered line by Dakota Johnson: 'He was in the Amazon with my mom when she was researching spiders right before she died.' This clunky exposition became a viral sensation on Twitter and TikTok, leading to endless parodies, remixes, and comparisons to the Morbius meme phenomenon. Beyond the dialogue, the meme captures the general so-bad-it-is-good sentiment surrounding the Sony Spider-Man Universe films. Users utilize the template to mock overly specific backstories or to ironically celebrate the movie's most campy and unintended comedic moments.