The 'Lowercase "nice." Downvotes' meme refers to a long-standing Reddit phenomenon known as 'Karma Roulette.' In a thread where users repeatedly comment 'Nice.' in response to a post—often involving the number 69 or 420—there is an unwritten rule that one specific comment in the chain must be heavily downvoted. While the selection is sometimes random, it frequently targets users who deviate from the established formatting, such as using a lowercase 'n' or adding extra punctuation. This meme captures the chaotic and unpredictable nature of Reddit's collective behavior, highlighting how a single typo or slight variation can lead to a massive landslide of negative internet points despite saying the exact same thing as everyone else.