Lori Lightfoot memes gained traction during her tenure as the 56th Mayor of Chicago, primarily due to her expressive facial features and distinctive public appearances. The memes often lean into her stern persona, which became particularly prominent during the COVID-19 pandemic when her image was used in viral 'Stay Home, Save Lives' campaigns. Many of the most popular variations play on her intense staring or specific wardrobe choices, which internet users adapt to represent feelings of disappointment, suspicion, or authoritative oversight. While some are politically charged, many simply use her unique aesthetic to convey a specific brand of chaotic yet disciplined energy that resonates across social media platforms.