The Lisa Simpson Coffee meme originates from 'The Simpsons' Season 4 episode 'Duffless,' where Lisa is depicted in a state of sleep-deprived agitation while attempting to complete a science project without her normal routine. The image features Lisa with wide, dilated pupils and a desperate grip on her mug, perfectly capturing the relatable essence of being 'wired' yet completely exhausted. It has since become a universal internet symbol for caffeine dependency, student burnout, and the frantic energy associated with looming deadlines. Users typically use the template to describe the internal chaos of trying to function while overwhelmed by stress or stimulants.