The 'Kill Me' meme is a versatile reaction image used to convey extreme frustration, embarrassment, or physical discomfort. While it has several cinematic origins—including the tragic Ripley clone in 'Alien Resurrection' and the fly-human hybrid in 'The Fly'—it gained massive internet popularity through the 'Meet the Medic' animated short for Team Fortress 2. In the video, the Spy's severed head remains alive in a refrigerator and utters the phrase 'Kill me' to the Medic, who nonchalantly replies 'Later.' Today, the meme is frequently applied to situations where someone feels trapped in an awkward social interaction, is overwhelmed by life, or is witnessing something deeply cringeworthy.