The 'Activate Instant Kill' meme originates from the Marvel Cinematic Universe, specifically appearing in Spider-Man: Homecoming and later in Avengers: Endgame. It features Peter Parker activating his suit's most lethal combat setting, which is visually signaled by his goggles glowing bright red. In internet culture, this template is used to represent an extreme, sudden, or overly aggressive reaction to a relatively minor provocation. It perfectly captures the 'zero to one hundred' escalation of anger or intensity, making it a staple for reaction memes involving gaming, social disagreements, or pet peeves.