The 'It's Anti-Italian Discrimination' meme features Silvio Dante from the HBO series The Sopranos, specifically from the episode 'Christopher.' In the scene, Silvio becomes outraged by protests against a Columbus Day parade, leading to his iconic outburst. The meme gained significant traction on social media as a humorous way to defend unpopular opinions or to mock someone acting overly defensive about their heritage or specific interests. It captures Silvio's quintessential New Jersey mobster intensity and has become a staple for fans of the show and internet culture enthusiasts alike who use it to facetiously shut down any criticism.