The 'Is This MF Serious? Does He Not Know We're Gonna' meme features a screenshot of comedian Eric André shrugging in his signature chaotic talk show setting. Taken from a Season 4 episode of The Eric André Show, the image captures Eric’s perfect mix of bafflement and reckless indifference. It gained viral traction on platforms like Twitter and Instagram as a reaction image used to mock someone's audacity or to signal that the speaker is about to engage in questionable behavior regardless of the consequences. The meme perfectly encapsulates the surreal humor of the show, making it a staple for online interactions involving disbelief or impending mischief.