The 'Who Killed Hannibal?' meme originates from a Season 2 episode of 'The Eric André Show,' where host Eric André abruptly shoots his co-host, Hannibal Buress, during a monologue. Immediately after the act, André turns to the camera and asks, 'Who killed Hannibal?', effectively blaming outside forces for a problem he personally caused. This template became a viral sensation for its perfect depiction of hypocrisy and the irony of shifting blame. It is frequently used to mock political figures, corporate decisions, or personal habits where the person responsible for a failure acts like a confused bystander.