The 'If It Ain't the Invisible Cunt' meme originates from the Amazon Prime Video series The Boys, specifically the first season where the protagonist Billy Butcher confronts the 'invisible' superhero Translucent. Butcher's gritty delivery and the blunt nature of the insult instantly turned the line into a viral hit. The meme is typically used to mock people who suddenly reappear after being absent, or to address someone who thinks they are being subtle or unseen. It captures a perfect blend of sarcasm, aggression, and dry humor, making it a favorite for fans of the show and reaction-image enthusiasts alike.