The 'Ice Spice Down Syndrome Theory' is a viral internet conspiracy that gained significant traction on platforms like TikTok and X (formerly Twitter) in early 2023. The theory suggests, often through ironic side-by-side comparisons, that the rapper Ice Spice possesses physical traits associated with Trisomy 21. While widely regarded as a baseless 'brain rot' trend or a form of dark humor, the meme has evolved into a staple of modern celebrity commentary. It is frequently used to mock the absurdity of internet sleuths or to lean into the chaotic, unfiltered nature of Gen Z humor, where shock value and controversy drive engagement.