The Lois Pills meme features Lois Griffin from the animated series Family Guy in a state of manic intensity while consuming a handful of pills. The image stems from the Season 11 episode 'The Big Fat Killer,' where Lois becomes addicted to Stewie's ADHD medication. On the internet, the template is widely used to represent hyper-fixation, addiction to a specific hobby, or the feeling of being overwhelmed but caffeinated. Its popularity endures as a relatable reaction for anyone who has ever gone 'all in' on something with a slightly unhinged level of enthusiasm.