The Don Toliver and Dr. Nefario comparison meme emerged as a viral sensation across social media platforms like Twitter and TikTok, where fans pointed out the striking resemblance between the Houston rapper and the eccentric scientist from the Despicable Me franchise. The visual comparison typically focuses on Toliver’s frequent use of large, rounded goggles, his head shape, and his hunched posture during performances, which uncannily mirror Dr. Nefario's animated design. This meme is widely used to humorously critique avant-garde hip-hop fashion or to highlight how life can sometimes imitate art in the most unexpected ways. It remains a popular trope within the music community, blending pop culture nostalgia with modern rap aesthetic commentary.